A Bellfield man faces a number of charges after being caught driving on the wrong side of the Hume Highway north of Melbourne on Saturday night.

Seymour Police say a number of witnesses saw the 35-year-old man driving a black Honda sedan south in northbound lanes, before he was intercepted by police and arrested at 10pm.

Police intend to charge the driver with reckless conduct and various other driving offences.

The driver returned an initial positive test for drugs and police have sent his blood for further testing.

A positive test on the blood sample will result in the man being charged with drug driving.