Police are investigating after a fatal collision at Whittingham last night.

About 5.15pm (Tuesday 29 December 2015), emergency services were called to the New England Highway, 5km south of Singleton, following reports of a two car collision.

Officers from Hunter Valley Local Area Command attended and found two cars, a VW utility and a Holden had collided head on.

The driver and sole occupant of the Holden, a woman, died at the scene.

There were four male occupants in the utility, the driver aged 21, and three passengers aged 40, 14 and 12, were taken to John Hunter Hospital with minor injuries.

Newcastle City Crash Investigation Unit attended and examined the scene.

The New England Highway was closed for a number of hours but has since re-opened.

Investigators are appealing for anyone who witnessed the collision or has information that may assist with their inquiries to call Crime Stoppers.

A report will be prepared for the information of the Coroner.