A man has died and his wife has been flown to hospital following a crash on the Hume Highway.

Emergency services were called to the highway between Wangaratta and Glenrowan about 2.40pm on Tuesday.

The couple’s Queensland registered car, which was towing a Victorian registered caravan, rolled onto its side leaving the couple trapped.

The man died as he was being freed by emergency services and his wife was flown to a Melbourne hospital.

The couple are believed to be aged between 60 and 70 and it is not known where they were from or where they were travelling to.

Their vehicle appeared to travel in a straight line before hitting a tree and did not brake, and police are investigating the cause.