Police are appealing for witnesses after a motorcyclist died following a two-vehicle crash near Goulburn on the weekend.

About 5.50pm (Sunday 13 March 2016), an 18-year-old man was riding a motorcycle south along the Hume Highway.

As the man approached Yarra, near Goulburn, he collided with the rear of a Toyota sedan travelling in the same direction, and he was thrown from the motorcycle.

Emergency services were called and the motorcyclist was treated at the scene, before being airlifted to Canberra Hospital in a critical condition.

The 26-year-old female driver of the Toyota was uninjured and taken to Goulburn Base Hospital for mandatory testing.

Yesterday (Monday 14 March 2016), the man died in hospital.

Officers attached to The Hume Local Area Command are investigating the incident, and are appealing for any witnesses who have not yet spoken to police to come forward.

A report will be prepared for the Coroner.