Police will address the media after a woman was arrested of a woman over the disappearance of Leonie Astra Hutchinson in the Hunter Valley 15 years ago.

Investigators believe Leonie was 16 months old when she disappeared from her home in Scone sometime around January 2001.

As a result of on-going inquiries, detectives attached to Strike Force Kanuna, arrested a 43-year-old woman at her home, in Evans Head, on the Far North Coast, about 7.30am today (Wednesday 16 March 2016).

The woman was taken to Lismore Police Station where she is expected to be charged with one count of murder.