A HIGH-speed police chase ended on the Hume Highway with an empty tank of fuel and two people in custody.

A white Ford sedan with a 26-year-old Geelong driver and 19-year-old Albury passenger first came to police attention about 8am on Tuesday.

The car had been travelling at high speed on the Murchison-Violet Town Road and was not pursued due to the conditions.

It was later seen travelling north on the Hume Highway at 150km/h about 9am, then on the Midland Highway heading to Benalla.

Police engaged and terminated pursuits several times before spotting the car near the northbound Glenrowan service station about 9.20am.

The vehicle had run out of fuel at the bottom of a hill.

The Geelong woman and Albury man have been charged.

Senior Constable Stuart Pritchard said the car was in poor condition with damaged tyres and panels.

He said the driver had been inexperienced and was a danger to the community.