Two people have been seriously injured following a crash north of Goulburn today.

About 2.40pm (Saturday 12 November 2016), police and emergency services were called to the Hume Highway, about 11km north of Goulburn, after reports of a crash involving two vehicles.

Police have been told an MG sedan and a Nissan Pulsar hatchback crashed while travelling north towards Sydney.

Two occupants of the MG, the 66-year-old male driver and his female passenger, were assessed at the scene by NSW Ambulance Paramedics and taken to Goulburn Base Hospital in a serious condition.

The female driver of the Nissan, 29, suffered minor injuries and was also taken to Goulburn Base Hospital for mandatory blood and urine testing.

Officers from Traffic and Highway Patrol Command have established a crime scene and the Crash Investigation Unit will investigate the circumstances surrounding the incident.

One northbound lane of the Hume Highway remains closed with delays expected for some time.

Drivers are urged to refer to www.livetraffic.com for the latest traffic information.